NRF2 DEFICIENCY IN MYELOID CELLS IS NOT SUFFICIENT TO PROTECT MICE FROM HFD-INDUCED ADIPOSE TISSUE INFLAMMATION AND INSULIN RESISTANCE

Activation of the transcription factor NF-E2 related factor 2 (Nrf2) by oxidative stress induces the expression of a variety of antioxidant and anti-inflammatory genes. Yet, genetic ablation of Nrf2 was shown to protect mice from high-fat diet (HFD)-induced obesity and insulin resistance. The mechan...

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Detalhes bibliográficos
Main Authors: Meher, Akshaya K., Sharma, Poonam R., Lira, Vitor A., Yamamoto, Masayuki, Kensler, Thomas W., Yan, Zhen, Leitinger, Norbert
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383807/
https://ncbi.nlm.nih.gov/pubmed/22370093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2012.02.022
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