I-SceI-Mediated Double-Strand Break Does Not Increase the Frequency of Homologous Recombination at the Dct Locus in Mouse Embryonic Stem Cells

Targeted induction of double-strand breaks (DSBs) at natural endogenous loci was shown to increase the rate of gene replacement by homologous recombination in mouse embryonic stem cells. The gene encoding dopachrome tautomerase (Dct) is specifically expressed in melanocytes and their precursors. To...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Fenina, Myriam, Simon-Chazottes, Dominique, Vandormael-Pournin, Sandrine, Soueid, Jihane, Langa, Francina, Cohen-Tannoudji, Michel, Bernard, Bruno A., Panthier, Jean-Jacques
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2012
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383693/
https://ncbi.nlm.nih.gov/pubmed/22761925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039895
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