I-SceI-Mediated Double-Strand Break Does Not Increase the Frequency of Homologous Recombination at the Dct Locus in Mouse Embryonic Stem Cells

Targeted induction of double-strand breaks (DSBs) at natural endogenous loci was shown to increase the rate of gene replacement by homologous recombination in mouse embryonic stem cells. The gene encoding dopachrome tautomerase (Dct) is specifically expressed in melanocytes and their precursors. To...

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Detalhes bibliográficos
Main Authors: Fenina, Myriam, Simon-Chazottes, Dominique, Vandormael-Pournin, Sandrine, Soueid, Jihane, Langa, Francina, Cohen-Tannoudji, Michel, Bernard, Bruno A., Panthier, Jean-Jacques
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383693/
https://ncbi.nlm.nih.gov/pubmed/22761925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039895
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