Zampanolide, a potent new microtubule stabilizing agent, covalently reacts with the taxane luminal site in both tubulin α,β-heterodimers and microtubules

Zampanolide and its less active analog dactylolide compete with paclitaxel for binding to microtubules and represent a new class of microtubule-stabilizing agent (MSA). Mass spectrometry demonstrated that the mechanism of action of both compounds involved covalent binding to β-tubulin at residues N2...

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Hoofdauteurs: Field, Jessica J., Pera, Benet, Calvo, Enrique, Canales, Angeles, Zurwerra, Didier, Trigili, Chiara, Rodríguez-Salarichs, Javier, Matesanz, Ruth, Kanakkanthara, Arun, Wakefield, St. John, Singh, A. Jonathan, Jiménez-Barbero, Jesús, Northcote, Peter, Miller, John H., López, Juan Antonio, Hamel, Ernest, Barasoain, Isabel, Altmann, Karl-Heinz, Díaz, José Fernando
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3383615/
https://ncbi.nlm.nih.gov/pubmed/22726683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.05.008
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