Human Peripheral Blood Mononuclear Cells Exhibit Heterogeneous CD52 Expression Levels and Show Differential Sensitivity to Alemtuzumab Mediated Cytolysis

Alemtuzumab is a monoclonal antibody that targets cell surface CD52 and is effective in depleting lymphocytes by cytolytic effects in vivo. Although the cytolytic effects of alemtuzumab are dependent on the density of CD52 antigen on cells, there is scant information regarding the expression levels...

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Detalhes bibliográficos
Main Authors: Rao, Sambasiva P., Sancho, Jose, Campos-Rivera, Juanita, Boutin, Paula M., Severy, Peter B., Weeden, Timothy, Shankara, Srinivas, Roberts, Bruce L., Kaplan, Johanne M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382607/
https://ncbi.nlm.nih.gov/pubmed/22761788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039416
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