Critical features for biosynthesis, stability, and functionality of a G protein-coupled receptor uncovered by all-versus-all mutations

The structural features determining efficient biosynthesis, stability in the membrane and, after solubilization, in detergents are not well understood for integral membrane proteins such as G protein-coupled receptors (GPCRs). Starting from the rat neurotensin receptor 1, a class A GPCR, we generate...

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Bibliographic Details
Main Authors: Schlinkmann, Karola M., Honegger, Annemarie, Türeci, Esin, Robison, Keith E., Lipovšek, Daša, Plückthun, Andreas
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382542/
https://ncbi.nlm.nih.gov/pubmed/22665811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202107109
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