A protein coevolution method uncovers critical features of the Hepatitis C Virus fusion mechanism

Amino-acid coevolution can be referred to mutational compensatory patterns preserving the function of a protein. Viral envelope glycoproteins, which mediate entry of enveloped viruses into their host cells, are shaped by coevolution signals that confer to viruses the plasticity to evade neutralizing...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Douam, Florian, Fusil, Floriane, Enguehard, Margot, Dib, Linda, Nadalin, Francesca, Schwaller, Loïc, Hrebikova, Gabriela, Mancip, Jimmy, Mailly, Laurent, Montserret, Roland, Ding, Qiang, Maisse, Carine, Carlot, Emilie, Xu, Ke, Verhoeyen, Els, Baumert, Thomas F., Ploss, Alexander, Carbone, Alessandra, Cosset, François-Loïc, Lavillette, Dimitri
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854445/
https://ncbi.nlm.nih.gov/pubmed/29505618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006908
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