SMAC mimetic (JP1201) sensitizes non-small cell lung cancers to multiple chemotherapy agents in an IAP dependent but TNFα independent manner

Inhibitors of apoptosis proteins (IAPs) are key regulators of apoptosis and are inhibited by the second mitocondrial activator of caspases (SMAC). Previously, a small subset of TNFα-expressing non-small cell lung cancers (NSCLCs) was found to be sensitive to SMAC mimetics alone. In this study we det...

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Détails bibliographiques
Auteurs principaux: Greer, Rachel M., Peyton, Michael, Larsen, Jill E., Girard, Luc, Xie, Yang, Gazdar, Adi, Harran, Patrick, Wang, Lai, Brekken, Rolf A., Wang, Xiaodong, Minna, John D.
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382117/
https://ncbi.nlm.nih.gov/pubmed/22049529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3947
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