Disrupted Autophagy Leads to Dopaminergic Axon and Dendrite Degeneration and Promotes Presynaptic Accumulation of α-Synuclein and LRRK2 in the Brain

Parkinson's disease (PD) is characterized pathologically by the formation of ubiquitin and α-synuclein (α-syn)-containing inclusions (Lewy bodies), dystrophic dopamine (DA) terminals, and degeneration of midbrain DA neurons. The precise molecular mechanisms underlying these pathological feature...

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Autori principali: Friedman, Lauren G., Lachenmayer, M. Lenard, Wang, Jing, He, Liqiang, Poulose, Shibu M., Komatsu, Masaaki, Holstein, Gay R., Yue, Zhenyu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2012
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382107/
https://ncbi.nlm.nih.gov/pubmed/22649237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5809-11.2012
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