Decreased Proteolytic Activity of the Mitochondrial Amyloid-β Degrading Enzyme, PreP Peptidasome, in Alzheimer's Disease Brain Mitochondria

Accumulation of amyloid-β peptide (Aβ), the neurotoxic peptide implicated in the pathogenesis of Alzheimer's disease (AD), has been shown in brain mitochondria of AD patients and of AD transgenic mouse models. The presence of Aβ in mitochondria leads to free radical generation and neuronal stre...

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Hlavní autoři: Alikhani, Nyosha, Guo, Lan, Yan, Shiqiang, Du, Heng, Pinho, Catarina Moreira, Chen, John Xi, Glaser, Elzbieta, Yan, Shirley ShiDu
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381900/
https://ncbi.nlm.nih.gov/pubmed/21750375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2011-101716
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