The amyloid β-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

The amyloid β-peptide (Aβ) has been suggested to exert its toxicity intracellularly. Mitochondrial functions can be negatively affected by Aβ and accumulation of Aβ has been detected in mitochondria. Because Aβ is not likely to be produced locally in mitochondria, we decided to investigate the mecha...

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Bibliografiske detaljer
Main Authors: Hansson Petersen, Camilla A., Alikhani, Nyosha, Behbahani, Homira, Wiehager, Birgitta, Pavlov, Pavel F., Alafuzoff, Irina, Leinonen, Ville, Ito, Akira, Winblad, Bengt, Glaser, Elzbieta, Ankarcrona, Maria
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2527349/
https://ncbi.nlm.nih.gov/pubmed/18757748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806192105
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