Apolipoprotein E4 effects in Alzheimer’s disease are mediated by synaptotoxic oligomeric amyloid-β

The apolipoprotein E ε4 gene is the most important genetic risk factor for sporadic Alzheimer’s disease, but the link between this gene and neurodegeneration remains unclear. Using array tomography, we analysed >50 000 synapses in brains of 11 patients with Alzheimer’s disease and five non-dement...

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Detalhes bibliográficos
Main Authors: Koffie, Robert M., Hashimoto, Tadafumi, Tai, Hwan-Ching, Kay, Kevin R., Serrano-Pozo, Alberto, Joyner, Daniel, Hou, Steven, Kopeikina, Katherine J., Frosch, Matthew P., Lee, Virginia M., Holtzman, David M., Hyman, Bradley T., Spires-Jones, Tara L.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381721/
https://ncbi.nlm.nih.gov/pubmed/22637583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/aws127
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