Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

Synapse loss correlates with a cognitive decline in Alzheimer's disease (AD), but whether this is caused by fibrillar deposits known as senile plaques or soluble oligomeric forms of amyloid β (Aβ) is controversial. By using array tomography, a technique that combines ultrathin sectioning of tis...

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Detalles Bibliográficos
Main Authors: Koffie, Robert M., Meyer-Luehmann, Melanie, Hashimoto, Tadafumi, Adams, Kenneth W., Mielke, Matthew L., Garcia-Alloza, Monica, Micheva, Kristina D., Smith, Stephen J., Kim, M. Leo, Lee, Virginia M., Hyman, Bradley T., Spires-Jones, Tara L.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2656196/
https://ncbi.nlm.nih.gov/pubmed/19228947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0811698106
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