Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis

Controlling maleimide hydrolysis allows the modular construction of bromomaleimide-mediated bioconjugates which are either stable or cleavable in an aqueous, thiol-mediated reducing environment. The application of this methodology to reversible protein biotinylation, the irreversible labeling of pep...

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Bibliografiske detaljer
Main Authors: Ryan, Chris P., Smith, Mark E. B., Schumacher, Felix F., Grohmann, Dina, Papaioannou, Danai, Waksman, Gabriel, Werner, Finn, Baker, James R., Caddick, Stephen
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2011
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381635/
https://ncbi.nlm.nih.gov/pubmed/21465057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c1cc11114k
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