siRNA-optimized Modifications for Enhanced In Vivo Activity

Current modifications used in small interfering RNAs (siRNAs), such as 2'-methoxy (2'-OMe) and 2'-fluoro (2'-F), improve stability, specificity or immunogenic properties but do not improve potency. These modifications were previously designed for use in antisense and not siRNA. W...

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Bibliografiske detaljer
Main Authors: Kenski, Denise M, Butora, Gabor, Willingham, Aarron T, Cooper, Abby J, Fu, Wenlang, Qi, Ning, Soriano, Ferdie, Davies, Ian W, Flanagan, W Michael
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381598/
https://ncbi.nlm.nih.gov/pubmed/23344622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2011.4
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