Formulation of Small Activating RNA Into Lipidoid Nanoparticles Inhibits Xenograft Prostate Tumor Growth by Inducing p21 Expression

Application of RNA interference (RNAi) in the clinic has improved with the development of novel delivery reagents (e.g., lipidoids). Although RNAi promises a therapeutic approach at silencing gene expression, practical methods for enhancing gene production still remain a challenge. Previously, we re...

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Detalhes bibliográficos
Main Authors: Place, Robert F, Wang, Ji, Noonan, Emily J, Meyers, Rachel, Manoharan, Muthiah, Charisse, Klaus, Duncan, Rick, Huang, Vera, Wang, Xiaoling, Li, Long-Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381590/
https://ncbi.nlm.nih.gov/pubmed/23343884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2012.5
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