Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design

Therapeutics based on small interfering RNA (siRNA) have promising potential as antiviral and anti-inflammatory agents. To deliver siRNA across cell membranes to reach the RNAi pathway in the cytosol of target cells, non-viral nanoparticulate delivery approaches are explored. Recently, we showed tha...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: de Groot, Anne Marit, Thanki, Kaushik, Gangloff, Monique, Falkenberg, Emily, Zeng, Xianghui, van Bijnen, Djai C.J., van Eden, Willem, Franzyk, Henrik, Nielsen, Hanne M., Broere, Femke, Gay, Nick J., Foged, Camilla, Sijts, Alice J.A.M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992342/
https://ncbi.nlm.nih.gov/pubmed/29858051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.02.003
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