Immunogenicity Testing of Lipidoids In Vitro and In Silico: Modulating Lipidoid-Mediated TLR4 Activation by Nanoparticle Design

Therapeutics based on small interfering RNA (siRNA) have promising potential as antiviral and anti-inflammatory agents. To deliver siRNA across cell membranes to reach the RNAi pathway in the cytosol of target cells, non-viral nanoparticulate delivery approaches are explored. Recently, we showed tha...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Ther Nucleic Acids
Auteurs principaux: de Groot, Anne Marit, Thanki, Kaushik, Gangloff, Monique, Falkenberg, Emily, Zeng, Xianghui, van Bijnen, Djai C.J., van Eden, Willem, Franzyk, Henrik, Nielsen, Hanne M., Broere, Femke, Gay, Nick J., Foged, Camilla, Sijts, Alice J.A.M.
Format: Artigo
Langue:Inglês
Publié: American Society of Gene & Cell Therapy 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992342/
https://ncbi.nlm.nih.gov/pubmed/29858051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.02.003
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