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Solution Structure of a Unique G-quadruplex Scaffold Adopted by a Guanosine-rich Human Intronic Sequence

We report on the solution structure of an unprecedented intramolecular G-quadruplex formed by the guanosine-rich human chl1 intronic d(G(3)-N-G(4)-N(2)-G(4)-N-G(3)-N) 19-mer sequence in K(+)-containing solution. This G-quadruplex, composed of three stacked G-tetrads containing four syn guanines, rep...

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Bibliographic Details
Main Authors: Kuryavyi, Vitaly, Patel, Dinshaw J.
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381514/
https://ncbi.nlm.nih.gov/pubmed/20152154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2009.10.015
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