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Role of Induced-Fit in Limiting Discrimination Against AZT by HIV Reverse Transcriptase
Single turnover kinetic studies were conducted using fluorescently labeled HIV Reverse Transcriptase (RT) to evaluate the role of nucleotide-induced changes in enzyme structure in the selectivity against AZT in order to explore why AZT-resistant forms of the enzyme fail to significantly discriminate...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3381507/ https://ncbi.nlm.nih.gov/pubmed/21548586 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200204m |
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