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Nucleotide-dependent conformational change governs specificity and analog discrimination by HIV reverse transcriptase
Single turnover studies on HIV reverse transcriptase suggest that nucleoside analogs bind more tightly to the enzyme than normal substrates, contrary to rational structural predictions. Here we resolve these controversies by monitoring the kinetics of nucleotide-induced changes in enzyme structure....
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2867896/ https://ncbi.nlm.nih.gov/pubmed/20385846 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913946107 |
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