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Structure of a Calcium-dependent 11R-Lipoxygenase Suggests a Mechanism for Ca(2+) Regulation

Lipoxygenases (LOXs) are a key part of several signaling pathways that lead to inflammation and cancer. Yet, the mechanisms of substrate binding and allosteric regulation by the various LOX isoforms remain speculative. Here we report the 2.47-Å resolution crystal structure of the arachidonate 11R-LO...

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Autores principales: Eek, Priit, Järving, Reet, Järving, Ivar, Gilbert, Nathaniel C., Newcomer, Marcia E., Samel, Nigulas
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381197/
https://ncbi.nlm.nih.gov/pubmed/22573333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.343285
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