Structural Basis for Small G Protein Effector Interaction of Ras-related Protein 1 (Rap1) and Adaptor Protein Krev Interaction Trapped 1 (KRIT1)

Cerebral cavernous malformations (CCMs) affect 0.1–0.5% of the population resulting in leaky vasculature and severe neurological defects. KRIT1 (Krev interaction trapped-1) mutations associate with ∼40% of familial CCMs. KRIT1 is an effector of Ras-related protein 1 (Rap1) GTPase. Rap1 relocalizes K...

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Detalles Bibliográficos
Main Authors: Li, Xiaofeng, Zhang, Rong, Draheim, Kyle M., Liu, Weizhi, Calderwood, David A., Boggon, Titus J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381192/
https://ncbi.nlm.nih.gov/pubmed/22577140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.361295
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