Transcriptional Repression of ATF4 Gene by CCAAT/Enhancer-binding Protein β (C/EBPβ) Differentially Regulates Integrated Stress Response

Different environmental stresses induce the phosphorylation of eIF2 (eIF2∼P), repressing global protein synthesis coincident with preferential translation of ATF4. ATF4 is a transcriptional activator of genes involved in metabolism and nutrient uptake, antioxidation, and regulation of apoptosis. Bec...

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Detalhes bibliográficos
Main Authors: Dey, Souvik, Savant, Sudha, Teske, Brian F., Hatzoglou, Maria, Calkhoven, Cornelis F., Wek, Ronald C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381154/
https://ncbi.nlm.nih.gov/pubmed/22556424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.351783
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