Interleukin-1β (IL-1β) transcriptionally activates hepcidin by inducing CCAAT enhancer-binding protein δ (C/EBPδ) expression in hepatocytes

Hepcidin is a liver-derived hormone that negatively regulates serum iron levels and is mainly regulated at the transcriptional level. Previous studies have clarified that in addition to hepatic iron levels, inflammation also efficiently increases hepatic hepcidin expression. The principle regions re...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Kanamori, Yohei, Murakami, Masaru, Sugiyama, Makoto, Hashimoto, Osamu, Matsui, Tohru, Funaba, Masayuki
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5473230/
https://ncbi.nlm.nih.gov/pubmed/28438835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.770974
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