Constitutive Cholesterol-dependent Endocytosis of Melanocortin-4 Receptor (MC4R) Is Essential to Maintain Receptor Responsiveness to α-Melanocyte-stimulating Hormone (α-MSH)

Melanocortin-4 receptor (MC4R) is a G-protein-coupled receptor expressed in the hypothalamus where it controls feeding behavior. MC4R cycles constitutively and is internalized at the same rate in the presence or absence of stimulation by the agonist, melanocyte-stimulating hormone (α-MSH). This is d...

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Bibliografski detalji
Glavni autori: McDaniel, Faith K., Molden, Brent M., Mohammad, Sameer, Baldini, Giovanna, McPike, Lakisha, Narducci, Paola, Granell, Susana, Baldini, Giulia
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Molecular Bases of Disease
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381150/
https://ncbi.nlm.nih.gov/pubmed/22544740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.346890
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