Constitutive Cholesterol-dependent Endocytosis of Melanocortin-4 Receptor (MC4R) Is Essential to Maintain Receptor Responsiveness to α-Melanocyte-stimulating Hormone (α-MSH)

Melanocortin-4 receptor (MC4R) is a G-protein-coupled receptor expressed in the hypothalamus where it controls feeding behavior. MC4R cycles constitutively and is internalized at the same rate in the presence or absence of stimulation by the agonist, melanocyte-stimulating hormone (α-MSH). This is d...

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Bibliographische Detailangaben
Hauptverfasser: McDaniel, Faith K., Molden, Brent M., Mohammad, Sameer, Baldini, Giovanna, McPike, Lakisha, Narducci, Paola, Granell, Susana, Baldini, Giulia
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3381150/
https://ncbi.nlm.nih.gov/pubmed/22544740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.346890
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