Mutagenic processing of ribonucleotides in DNA by yeast topoisomerase 1

The RNase H class of enzymes degrades the RNA component of RNA:DNA hybrids and is important in nucleic acid metabolism. RNase H2 is specialized to remove single ribonucleotides (rNMPs) from duplex DNA, and its absence in budding yeast has been associated with the accumulation of deletions within sho...

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Main Authors: Kim, Nayun, Huang, Sharyin N., Williams, Jessica, Li, Yue C., Clark, Alan B., Cho, Jang-Eun, Kunkel, Thomas A., Pommier, Yves, Jinks-Robertson, Sue
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380281/
https://ncbi.nlm.nih.gov/pubmed/21700875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1205016
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