Ubiquitylation of the initiator caspase DREDD is required for innate immune signalling

Caspases have been extensively studied as critical initiators and executioners of cell death pathways. However, caspases also take part in non-apoptotic signalling events such as the regulation of innate immunity and activation of nuclear factor-κB (NF-κB). How caspases are activated under these con...

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Main Authors: Meinander, Annika, Runchel, Christopher, Tenev, Tencho, Chen, Li, Kim, Chan-Hee, Ribeiro, Paulo S, Broemer, Meike, Leulier, Francois, Zvelebil, Marketa, Silverman, Neal, Meier, Pascal
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380211/
https://ncbi.nlm.nih.gov/pubmed/22549468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.121
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