Inactivation of Effector Caspases through Nondegradative Polyubiquitylation

Ubiquitin-mediated inactivation of caspases has long been postulated to contribute to the regulation of apoptosis. However, detailed mechanisms and functional consequences of caspase ubiquitylation have not been demonstrated. Here we show that the Drosophila Inhibitor of Apoptosis 1, DIAP1, blocks e...

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Detalhes bibliográficos
Main Authors: Ditzel, Mark, Broemer, Meike, Tenev, Tencho, Bolduc, Clare, Lee, Tom V., Rigbolt, Kristoffer T.G., Elliott, Richard, Zvelebil, Marketa, Blagoev, Blagoy, Bergmann, Andreas, Meier, Pascal
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713662/
https://ncbi.nlm.nih.gov/pubmed/19026784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.09.025
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