Inactivation of Effector Caspases through Nondegradative Polyubiquitylation

Ubiquitin-mediated inactivation of caspases has long been postulated to contribute to the regulation of apoptosis. However, detailed mechanisms and functional consequences of caspase ubiquitylation have not been demonstrated. Here we show that the Drosophila Inhibitor of Apoptosis 1, DIAP1, blocks e...

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Hlavní autoři: Ditzel, Mark, Broemer, Meike, Tenev, Tencho, Bolduc, Clare, Lee, Tom V., Rigbolt, Kristoffer T.G., Elliott, Richard, Zvelebil, Marketa, Blagoev, Blagoy, Bergmann, Andreas, Meier, Pascal
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713662/
https://ncbi.nlm.nih.gov/pubmed/19026784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.09.025
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