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Metabolism of Cr(VI) by ascorbate but not glutathione is a low oxidant-generating process
Genotoxic activity of hexavalent chromium (chromate) results from its reductive activation inside the cell. Cr(VI) metabolism in vivo is primarily driven by ascorbate (Asc) but in cultured cells by glutathione (GSH). Given the common use of cultured cells for mechanistic studies, it is important to...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3380165/ https://ncbi.nlm.nih.gov/pubmed/22572042 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtemb.2012.04.016 |
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