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9-Mercaptodethiobiotin is Formed as a Competent Catalytic Intermediate by Escherichia coli Biotin Synthase

Biotin synthase (BS) catalyzes the oxidative addition of a sulfur atom to dethiobiotin (DTB) to generate the biotin thiophane ring. This enzyme is an S-adenosylmethionine (AdoMet) radical enzyme that catalyzes the reductive cleavage of AdoMet, generating methionine and a transient 5´-deoxyadenosyl r...

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Autors principals: Taylor, Andrew M., Farrar, Christine E., Jarrett, Joseph T.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3380106/
https://ncbi.nlm.nih.gov/pubmed/18690713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801035b
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