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Anesthetic Isoflurane Increases Phosphorylated Tau Levels Mediated by Caspase Activation and Aβ Generation

Anesthetic isoflurane has been shown to promote Alzheimer’s disease (AD) neuropathogenesis by inducing caspase activation and accumulation of β-amyloid (Aβ). Phosphorylation of tau protein is another important feature of AD neuropathogenesis. However, the effects of isoflurane on phosphorylated tau...

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Autori principali: Dong, Yuanlin, Wu, Xu, Xu, Zhipeng, Zhang, Yiying, Xie, Zhongcong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3379981/
https://ncbi.nlm.nih.gov/pubmed/22745746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039386
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