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The Potential Dual Effects of Anesthetic Isoflurane on Hypoxia-Induced Caspase-3 Activation and Increases in β-Site Amyloid Precursor Protein-Cleaving Enzyme Levels

BACKGROUND: β-amyloid protein (Aβ) accumulation, caspase activation, apoptosis, and hypoxia-induced neurotoxicity have been suggested to be involved in Alzheimer disease neuropathogenesis. Aβ is produced from amyloid precursor protein (APP) through proteolytic processing by the aspartyl protease β-s...

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Detalhes bibliográficos
Main Authors: Pan, Chuxiong, Xu, Zhipeng, Dong, Yuanlin, Zhang, Yiying, Zhang, Jun, McAuliffe, Sayre, Yue, Yun, Li, Tianzuo, Xie, Zhongcong
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3123429/
https://ncbi.nlm.nih.gov/pubmed/21519046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0b013e3182185fee
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