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Structure–Activity Relationship for Thiirane-Based Gelatinase Inhibitors
[Image: see text] An extensive structure–activity relationship study with the template of 2-(4-phenoxyphenylsulfonylmethyl)thiirane (1), a potent and highly selective inhibitor for human gelatinases, is reported herein. Syntheses of 65 new analogues, each in multistep processes, allowed for explorat...
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| Autors principals: | , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American
Chemical Society
2012
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| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3379896/ https://ncbi.nlm.nih.gov/pubmed/22737278 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300050b |
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