Active Site Ring-Opening of a Thiirane Moiety and Picomolar Inhibition of Gelatinases

(±)-2-[(4-Phenoxyphenylsulfonyl)methyl]thiirane 1 is a potent and selective mechanism-based inhibitor of the gelatinase sub-class of the zinc-dependent matrix metalloproteinase (MMP) family. Inhibitor 1 has excellent activity in in vivo models of gelatinase-dependent disease. We demonstrate that the...

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Bibliografiske detaljer
Main Authors: Forbes, Christopher, Shi, Qicun, Fisher, Jed F, Lee, Mijoon, Hesek, Dusan, Llarrull, Leticia I, Toth, Marta, Gossing, Michael, Fridman, Rafael, Mobashery, Shahriar
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2837476/
https://ncbi.nlm.nih.gov/pubmed/19807733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2009.00881.x
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