Structure–Activity Relationship for Thiirane-Based Gelatinase Inhibitors

[Image: see text] An extensive structure–activity relationship study with the template of 2-(4-phenoxyphenylsulfonylmethyl)thiirane (1), a potent and highly selective inhibitor for human gelatinases, is reported herein. Syntheses of 65 new analogues, each in multistep processes, allowed for explorat...

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Detalhes bibliográficos
Main Authors: Lee, Mijoon, Ikejiri, Masahiro, Klimpel, Dennis, Toth, Marta, Espahbodi, Mana, Hesek, Dusan, Forbes, Christopher, Kumarasiri, Malika, Noll, Bruce C., Chang, Mayland, Mobashery, Shahriar
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3379896/
https://ncbi.nlm.nih.gov/pubmed/22737278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300050b
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