Benznidazole-Resistance in Trypanosoma cruzi Is a Readily Acquired Trait That Can Arise Independently in a Single Population

Benznidazole is the frontline drug used against Trypanosoma cruzi, the causative agent of Chagas disease. However, treatment failures are often reported. Here, we demonstrate that independently acquired mutations in the gene encoding a mitochondrial nitroreductase (TcNTR) can give rise to distinct d...

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Detalhes bibliográficos
Main Authors: Mejia, Ana Maria, Hall, Belinda S., Taylor, Martin C., Gómez-Palacio, Andrés, Wilkinson, Shane R., Triana-Chávez, Omar, Kelly, John M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3379838/
https://ncbi.nlm.nih.gov/pubmed/22551809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jis331
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