Benznidazole-Resistance in Trypanosoma cruzi Is a Readily Acquired Trait That Can Arise Independently in a Single Population

Benznidazole is the frontline drug used against Trypanosoma cruzi, the causative agent of Chagas disease. However, treatment failures are often reported. Here, we demonstrate that independently acquired mutations in the gene encoding a mitochondrial nitroreductase (TcNTR) can give rise to distinct d...

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Bibliografiske detaljer
Main Authors: Mejia, Ana Maria, Hall, Belinda S., Taylor, Martin C., Gómez-Palacio, Andrés, Wilkinson, Shane R., Triana-Chávez, Omar, Kelly, John M.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2012
Fag:
Major Articles and Brief Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3379838/
https://ncbi.nlm.nih.gov/pubmed/22551809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jis331
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