Prostaglandin F2α synthase in Trypanosoma cruzi plays critical roles in oxidative stress and susceptibility to benznidazole

Nifurtimox (Nfx) and benznidazole (Bz) are the current drugs used for the treatment of Chagas disease. The mechanisms of action and resistance to these drugs in this parasite are poorly known. Prostaglandin F2α synthase or old yellow enzyme (OYE), an NAD(P)H flavin oxidoreductase, has been involved...

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Bibliographic Details
Published in:R Soc Open Sci
Main Authors: García-Huertas, Paola, Mejía-Jaramillo, Ana María, Machado, Carlos Renato, Guimarães, Anna Cláudia, Triana-Chávez, Omar
Format: Artigo
Language:Inglês
Published: The Royal Society Publishing 2017
Subjects:
Cellular and Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5627119/
https://ncbi.nlm.nih.gov/pubmed/28989779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsos.170773
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