Buthionine Sulfoximine Increases the Toxicity of Nifurtimox and Benznidazole to Trypanosoma cruzi

l-Buthionine (S,R)-sulfoximine (BSO) increased the toxicity of nifurtimox and benznidazole toward the epimastigote, trypomastigote, and amastigote forms of Trypanosoma cruzi. BSO at 500 μM decreased total glutathione-derived thiols by 70 to 80% in 48 h. In epimastigotes, 500 μM BSO decreased the con...

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Main Authors: Faundez, Mario, Pino, Laura, Letelier, Paula, Ortiz, Carla, López, Rodrigo, Seguel, Claudia, Ferreira, Jorge, Pavani, Mario, Morello, Antonio, Maya, Juan Diego
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2005
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Mechanisms of Action: Physiological Effects
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC538915/
https://ncbi.nlm.nih.gov/pubmed/15616285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.1.126-130.2005
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