Pharmacological Validation of Trypanosoma brucei Phosphodiesterases as Novel Drug Targets

The development of drugs for neglected infectious diseases often uses parasite-specific enzymes as targets. We here demonstrate that parasite enzymes with highly conserved human homologs may represent a promising reservoir of new potential drug targets. The cyclic nucleotide-specific phosphodiestera...

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Hlavní autoři: de Koning, Harry P., Gould, Matthew K., Sterk, Geert Jan, Tenor, Hermann, Kunz, Stefan, Luginbuehl, Edith, Seebeck, Thomas
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
Major Articles and Brief Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3379837/
https://ncbi.nlm.nih.gov/pubmed/22291195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jir857
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