Pharmacological Validation of Trypanosoma brucei Phosphodiesterases B1 and B2 as Druggable Targets for African Sleeping Sickness

Neglected tropical disease drug discovery requires application of pragmatic and efficient methods for development of new therapeutic agents. In this report we describe our target repurposing efforts for the essential phosphodiesterase (PDE) enzymes TbrPDEB1 and TbrPDEB2 of Trypanosoma brucei, the ca...

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Detalhes bibliográficos
Main Authors: Bland, Nicholas D., Wang, Cuihua, Tallman, Craig, Gustafson, Alden E., Wang, Zhouxi, Ashton, Trent D., Ochiana, Stefan O., McAllister, Gregory, Cotter, Kristina, Fang, Anna P., Gechijian, Lara, Garceau, Norman, Gangurde, Rajiv, Ortenberg, Ron, Ondrechen, Mary Jo, Campbell, Robert K., Pollastri, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228873/
https://ncbi.nlm.nih.gov/pubmed/22023548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201148s
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