Pharmacological Validation of Trypanosoma brucei Phosphodiesterases B1 and B2 as Druggable Targets for African Sleeping Sickness

Neglected tropical disease drug discovery requires application of pragmatic and efficient methods for development of new therapeutic agents. In this report we describe our target repurposing efforts for the essential phosphodiesterase (PDE) enzymes TbrPDEB1 and TbrPDEB2 of Trypanosoma brucei, the ca...

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Hlavní autoři: Bland, Nicholas D., Wang, Cuihua, Tallman, Craig, Gustafson, Alden E., Wang, Zhouxi, Ashton, Trent D., Ochiana, Stefan O., McAllister, Gregory, Cotter, Kristina, Fang, Anna P., Gechijian, Lara, Garceau, Norman, Gangurde, Rajiv, Ortenberg, Ron, Ondrechen, Mary Jo, Campbell, Robert K., Pollastri, Michael P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228873/
https://ncbi.nlm.nih.gov/pubmed/22023548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201148s
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