Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. 2. Tadalafil analogs

In this report we describe our ongoing target repurposing efforts focused on discovery of inhibitors of the essential trypanosomal phosphodiesterase TbrPDEB1. This enzyme has been implicated in virulence of Trypanosoma brucei, the causative agent of human African trypanosomiasis (HAT). We outline th...

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Bibliografiset tiedot
Päätekijät: Ochiana, Stefan O., Gustafson, Alden, Bland, Nicholas, Wang, Cuihua, Russo, Michael J., Campbell, Robert K., Pollastri, Michael P.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2012
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307956/
https://ncbi.nlm.nih.gov/pubmed/22377518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.01.118
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