Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas

Medulloblastomas account for 20% of pediatric brain tumors. With an overall survival of 40%–70%, their treatment is still a challenge. The majority of medulloblastomas lack p53 mutations, but even in cancers retaining wild-type p53, the tumor surveillance function of p53 is inhibited by the oncoprot...

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Autori principali: Künkele, Annette, De Preter, Katleen, Heukamp, Lukas, Thor, Theresa, Pajtler, Kristian W., Hartmann, Wolfgang, Mittelbronn, Michel, Grotzer, Michael A., Deubzer, Hedwig E., Speleman, Frank, Schramm, Alexander, Eggert, Angelika, Schulte, Johannes H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2012
Soggetti:
Basic and Translational Investigations
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3379802/
https://ncbi.nlm.nih.gov/pubmed/22591662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos115
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