The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma models

Polo-like kinase 1 (PLK1) is a serine/threonine kinase that promotes G2/M-phase transition, is expressed in elevated levels in high-risk neuroblastomas and correlates with unfavorable patient outcome. Recently, we and others have presented PLK1 as a potential drug target for neuroblastoma, and repor...

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Vydáno v:Oncotarget
Hlavní autoři: Pajtler, Kristian W, Sadowski, Natalie, Ackermann, Sandra, Althoff, Kristina, Schönbeck, Kerstin, Batzke, Katharina, Sch, Simonäfers, Odersky, Andrea, Heukamp, Lukas, Astrahantseff, Kathy, Künkele, Annette, Deubzer, Hedwig E, Schramm, Alexander, Spr, Annikaüssel, Thor, Theresa, Lindner, Sven, Eggert, Angelika, Fischer, Matthias, Schulte, Johannes H
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5351666/
https://ncbi.nlm.nih.gov/pubmed/28036269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14268
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