The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma models

Polo-like kinase 1 (PLK1) is a serine/threonine kinase that promotes G2/M-phase transition, is expressed in elevated levels in high-risk neuroblastomas and correlates with unfavorable patient outcome. Recently, we and others have presented PLK1 as a potential drug target for neuroblastoma, and repor...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Pajtler, Kristian W, Sadowski, Natalie, Ackermann, Sandra, Althoff, Kristina, Schönbeck, Kerstin, Batzke, Katharina, Sch, Simonäfers, Odersky, Andrea, Heukamp, Lukas, Astrahantseff, Kathy, Künkele, Annette, Deubzer, Hedwig E, Schramm, Alexander, Spr, Annikaüssel, Thor, Theresa, Lindner, Sven, Eggert, Angelika, Fischer, Matthias, Schulte, Johannes H
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5351666/
https://ncbi.nlm.nih.gov/pubmed/28036269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14268
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