Inhibiting PHGDH with NCT-503 reroutes glucose-derived carbons into the TCA cycle, independently of its on-target effect

The small-molecule inhibitor of phosphoglycerate dehydrogenase, NCT-503, reduces incorporation of glucose-derived carbons into serine in vitro. Here we describe an off-target effect of NCT-503 in neuroblastoma cell lines expressing divergent phosphoglycerate dehydrogenase (PHGDH) levels and single-c...

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Bibliografski detalji
Izdano u:J Enzyme Inhib Med Chem
Glavni autori: Arlt, Birte, Mastrobuoni, Guido, Wuenschel, Jasmin, Astrahantseff, Kathy, Eggert, Angelika, Kempa, Stefan, Deubzer, Hedwig E.
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2021
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8253182/
https://ncbi.nlm.nih.gov/pubmed/34192988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2021.1935917
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