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Synthesis and evaluation of novel tropane derivatives as potential PET imaging agents for the dopamine transporter

A novel series of tropane derivatives containing a fluorinated tertiary amino or amide at the 2β position was synthesized, labeled with the positron-emitter fluorine-18 (T(1/2) = 109.8 min), and tested as potential in vivo dopamine transporter (DAT) imaging agents. The corresponding chlorinated anal...

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書誌詳細
主要な著者: Qiao, Hongwen, Zhu, Lin, Lieberman, Brian P., Zha, Zhihao, Plössl, Karl, Kung, Hank F.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378994/
https://ncbi.nlm.nih.gov/pubmed/22658558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.05.030
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