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In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important
Small interfering RNAs (siRNAs) are promising new active compounds in gene medicine but the induction of non-specific immune responses following their delivery continues to be a serious problem. With the purpose of avoiding such effects chemically modified siRNAs are tested in screening assay but of...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3378874/ https://ncbi.nlm.nih.gov/pubmed/22287630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks033 |
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