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In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important

Small interfering RNAs (siRNAs) are promising new active compounds in gene medicine but the induction of non-specific immune responses following their delivery continues to be a serious problem. With the purpose of avoiding such effects chemically modified siRNAs are tested in screening assay but of...

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Détails bibliographiques
Auteurs principaux: Schyth, Brian Dall, Bramsen, Jesper Bertram, Pakula, Malgorzata Maria, Larashati, Sekar, Kjems, Jørgen, Wengel, Jesper, Lorenzen, Niels
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2012
Sujets:
RNA
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378874/
https://ncbi.nlm.nih.gov/pubmed/22287630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks033
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